Dr. Cécile M. Ronckers (Ph.D.)

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• (Childhood) Cancer Survivorship
  • Zweittumore
  • Spätfolgen nach Strahlentherapie im Kindesalter
  • Methoden der Spätfolgenforschung
  • Leitlinien für Spät-und langzeitfolgen-versorgung
• (Kinder-) Krebsepidemiologie
• Spätfolgen radiologischer Expositionen

PubMed

Spätfolgen nach medizinscher Strahlenexposition im Kindesalter

Constine LS, Marks LB, Milano MT, Ronckers CM, Jackson A, Hudson MM, Marcus KJ, Hodgson DC, Hua CH, Howell RM, Marples B, Yorke E, Olch A, Bentzen SM. A User's Guide and Summary of Pediatric Normal Tissue Effects in the Clinic (PENTEC): Radiation Dose-Volume Response for Adverse Effects After Childhood Cancer Therapy and Future Directions. Int J Radiat Oncol Biol Phys. 2024 Jun 1;119(2):321-337. doi: 10.1016/j.ijrobp.2023.09.005. Epub 2023 Nov 23. PMID: 37999712.

Bentzen SM, Vogelius IR, Hodgson D, Howell R, Jackson A, Hua CH, Olch AJ, Ronckers C, Kremer L, Milano M, Marks LB, Constine LS. Radiation Dose-Volume-Response Relationships for Adverse Events in Childhood Cancer Survivors: Introduction to the Scientific Issues in PENTEC. Int J Radiat Oncol Biol Phys. 2024 Jun 1;119(2):338-353. doi: 10.1016/j.ijrobp.2023.11.028. PMID: 38760115.

Diallo I, Allodji RS, Veres C, Bolle S, Llanas D, Ezzouhri S, Zrafi W, Debiche G, Souchard V, Fauchery R, Haddy N, Journy N, Demoor-Goldschmidt C, Winter DL, Hjorth L, Wiebe T, Haupt R, Robert C, Kremer L, Bardi E, Sacerdote C, Terenziani M, Kuehni CE, Schindera C, Skinner R, Winther JF, Lähteenmäki P, Byrn J, Jakab Z, Cardis E, Pasqual E, Tapio S, Baatout S, Atkinson M, Benotmane MA, Sugden E, Zaletel LZ, Ronckers C, Reulen RC, Hawkins MM, de Vathaire F. Radiation Doses Received by Major Organs at Risk in Children and Young Adolescents Treated for Cancer with External Beam Radiation Therapy: A Large-scale Study from 12 European Countries. Int J Radiat Oncol Biol Phys. 2024 Oct 1;120(2):439-453. doi: 10.1016/j.ijrobp.2024.03.032. Epub 2024 Apr 4. PMID: 38582233.

Roberti S, van Leeuwen FE, Ronckers CM, Krul IM, de Vathaire F, Veres C, Diallo I, Janus CPM, Aleman BMP, Russell NS, Hauptmann M. Radiotherapy-Related Dose and Irradiated Volume Effects on Breast Cancer Risk Among Hodgkin Lymphoma Survivors. J Natl Cancer Inst. 2022 Sep 9;114(9):1270-1278. doi: 10.1093/jnci/djac125. PMID: 35771630; PMCID: PMC9468297.

Berrington de Gonzalez A, Vikram B, Buchsbaum JC, de Vathaire F, Dörr W, Hass-Kogan D, Langendijk JA, Mahajan A, Newhauser W, Ottolenghi A, Ronckers C, Schulte R, Walsh L, Yock TI, Kleinerman RA. A Clarion Call for Large-Scale Collaborative Studies of Pediatric Proton Therapy. Int J Radiat Oncol Biol Phys. 2017 Aug 1;98(5):980-981. doi: 10.1016/j.ijrobp.2017.03.033. Epub 2017 Jul 10. PMID: 28721911.

Kok JL, Teepen JC, van Leeuwen FE, Tissing WJE, Neggers SJCMM, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, van der Heiden-van der Loo M, Aleman BMP, Daniels LA, Haasbeek CJA, Hoeben B, Janssens GO, Maduro JH, Oldenburger F, van Rij C, Tersteeg RJHA, Hauptmann M; DCOG-LATER Study Group; Kremer LCM, Ronckers CM. Risk of benign meningioma after childhood cancer in the DCOG-LATER cohort: contributions of radiation dose, exposed cranial volume, and age. Neuro Oncol. 2019 Feb 19;21(3):392-403. doi: 10.1093/neuonc/noy124. PMID: 30099534; PMCID: PMC6380414.

van Dijk IW, van der Pal HJ, van Os RM, Roos YB, Sieswerda E, van Dalen EC, Ronckers CM, Oldenburger F, van Leeuwen FE, Caron HN, Koning CC, Kremer LC. Risk of Symptomatic Stroke After Radiation Therapy for Childhood Cancer: A Long-Term Follow-Up Cohort Analysis. Int J Radiat Oncol Biol Phys. 2016 Nov 1;96(3):597-605. doi: 10.1016/j.ijrobp.2016.03.049. Epub 2016 Apr 8. PMID: 27325477.

Schoot RA, Slater O, Ronckers CM, Zwinderman AH, Balm AJ, Hartley B, van den Brekel MW, Gupta S, Saeed P, Gajdosova E, Pieters BR, Gaze MN, Mandeville HC, Fajardo RD, Chang YC, Gains JE, Strackee SD, Dunaway D, Abela C, Mason C, Smeele LE, Chisholm JC, Levitt GA, Kremer LC, Grootenhuis MA, Maurice-Stam H, Stiller CA, Hammond P, Caron HN, Merks JH. Adverse events of local treatment in long-term head and neck rhabdomyosarcoma survivors after external beam radiotherapy or AMORE treatment. Eur J Cancer. 2015 Jul;51(11):1424-34. doi: 10.1016/j.ejca.2015.02.010. Epub 2015 May 18. PMID: 25998323.

Ronckers CM, Doody MM, Lonstein JE, Stovall M, Land CE. Multiple diagnostic X-rays for spine deformities and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):605-13. doi: 10.1158/1055-9965.EPI-07-2628. PMID: 18349278.

Meulepas JM, Ronckers CM, Smets AMJB, Nievelstein RAJ, Gradowska P, Lee C, Jahnen A, van Straten M, de Wit MY, Zonnenberg B, Klein WM, Merks JH, Visser O, van Leeuwen FE, Hauptmann M. Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands. J Natl Cancer Inst. 2019 Mar 1;111(3):256-263. doi: 10.1093/jnci/djy104. Erratum in: J Natl Cancer Inst. 2018 Oct 1;110(10):1154. doi: 10.1093/jnci/djy158. PMID: 30020493; PMCID: PMC6657440.

Methoden der Spätfolgenforschung

Teepen JC, Kok JL, Feijen EAM, Loonen JJ, van den Heuvel-Eibrink MM, van der Pal HJ, Tissing WJE, Bresters D, Versluys B, Grootenhuis MA, Louwerens M, Neggers SJCMM, van Santen HM, de Vries A, Janssens GO, den Hartogh JG, van Leeuwen FE, Hollema N, Streefkerk N, Kilsdonk E, van der Heiden-van der Loo M, van Dulmen-den Broeder E, Ronckers CM, Kremer LCM; DCCSS LATER Study Group. Questionnaire- and linkage-based outcomes in Dutch childhood cancer survivors: Methodology of the DCCSS LATER study part 1. Cancer Med. 2023 Mar;12(6):7588-7602. doi: 10.1002/cam4.5519. Epub 2022 Dec 15. PMID: 36519590; PMCID: PMC10067029.

Beijer JGM, Kok JL, Janssens GO, Streefkerk N, de Vries ACH, Slagter C, Maduro JH, Kroon PS, Grootenhuis MA, van Dulmen-den Broeder E, Loonen JJ, Wendling M, Tissing WJE, van der Pal HJ, Louwerens M, Bel A, den Hartogh J, van der Heiden-van der Loo M, Kremer LCM, Teepen JC, Ronckers CM. Adverse late health outcomes among children treated with 3D radiotherapy techniques: Study design of the Dutch pediatric 3D-RT study. Cancer Rep (Hoboken). 2023 Feb;6(2):e1620. doi: 10.1002/cnr2.1620. Epub 2023 Jan 30. PMID: 36715495; PMCID: PMC9939987.

Kovalchik SA, Ronckers CM, Veiga LH, Sigurdson AJ, Inskip PD, de Vathaire F, Sklar CA, Donaldson SS, Anderson H, Bhatti P, Hammond S, Leisenring WM, Mertens AC, Smith SA, Stovall M, Tucker MA, Weathers RE, Robison LL, Pfeiffer RM. Absolute risk prediction of second primary thyroid cancer among 5-year survivors of childhood cancer. J Clin Oncol. 2013 Jan 1;31(1):119-27. doi: 10.1200/JCO.2012.41.8996. Epub 2012 Nov 19. Erratum in: J Clin Oncol. 2013 Feb 20;31(6):824. PMID: 23169509; PMCID: PMC3530689.

Ronckers CM, Sigurdson AJ, Stovall M, Smith SA, Mertens AC, Liu Y, Hammond S, Land CE, Neglia JP, Donaldson SS, Meadows AT, Sklar CA, Robison LL, Inskip PD. Thyroid cancer in childhood cancer survivors: a detailed evaluation of radiation dose response and its modifiers. Radiat Res. 2006 Oct;166(4):618-28. doi: 10.1667/RR3605.1. PMID: 17007558.

Subsequent tumors

Wang Y, Ronckers CM, van Leeuwen FE, Moskowitz CS, Leisenring W, Armstrong GT, de Vathaire F, Hudson MM, Kuehni CE, Arnold MA, Demoor-Goldschmidt C, Green DM, Henderson TO, Howell RM, Ehrhardt MJ, Neglia JP, Oeffinger KC, van der Pal HJH, Robison LL, Schaapveld M, Turcotte LM, Waespe N, Kremer LCM, Teepen JC; International Consortium for Pooled Studies on Subsequent Malignancies after Childhood and Adolescent Cancer. Subsequent female breast cancer risk associated with anthracycline chemotherapy for childhood cancer. Nat Med. 2023 Sep;29(9):2268-2277. doi: 10.1038/s41591-023-02514-1. Epub 2023 Sep 11. PMID: 37696934; PMCID: PMC10504074.
 

Moskowitz CS, Ronckers CM, Chou JF, Smith SA, Friedman DN, Barnea D, Kok JL, de Vries S, Wolden SL, Henderson TO, van der Pal HJH, Kremer LCM, Neglia JP, Turcotte LM, Howell RM, Arnold MA, Schaapveld M, Aleman B, Janus C, Versluys B, Leisenring W, Sklar CA, Begg CB, Pike MC, Armstrong GT, Robison LL, van Leeuwen FE, Oeffinger KC. Development and Validation of a Breast Cancer Risk Prediction Model for Childhood Cancer Survivors Treated With Chest Radiation: A Report From the Childhood Cancer Survivor Study and the Dutch Hodgkin Late Effects and LATER Cohorts. J Clin Oncol. 2021 Sep 20;39(27):3012-3021. doi: 10.1200/JCO.20.02244. Epub 2021 May 28. PMID: 34048292; PMCID: PMC9384912.

Heymer EJ, Jóźwiak K, Kremer LC, Winter DL, de Vathaire F, Sunguc C, Sugden E, Kok JL, van der Pal HJH, Hjorth L, Jakab Z, Maule MM, Haupt R, Bagnasco F, Terenziani M, Diallo I, Gunnes MW, Sommer G, Zadravec Zaletel L, Kuehni CE, Winther JF, Lähteenmäki PM, Gudmundsdottir T, Allodji RS, Skinner R, Ronckers CM, Hawkins MM, Reulen RC, Teepen JC. Cumulative Absolute Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors: A PanCareSurFup Study. J Clin Oncol. 2024 Jan 20;42(3):336-347. doi: 10.1200/JCO.23.00452. Epub 2023 Nov 16. PMID: 37972325.

Kok JL, Teepen JC, van der Pal HJ, van Leeuwen FE, Tissing WJE, Neggers SJCMM, Loonen JJ, Louwerens M, Versluys B, van den Heuvel-Eibrink MM, van Dulmen-den Broeder E, Jaspers MMW, van Santen HM, van der Heiden-van der Loo M, Janssens GO, Maduro JH, Bruggink AH, Jongmans MC, Kremer LCM, Ronckers CM; DCOG-LATER Study Group. Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors Among Long-term Survivors of Childhood Cancer. JAMA Oncol. 2019 May 1;5(5):671-680. doi: 10.1001/jamaoncol.2018.6862. PMID: 30920605; PMCID: PMC6512289.

Teepen JC, van Leeuwen FE, Tissing WJ, van Dulmen-den Broeder E, van den Heuvel-Eibrink MM, van der Pal HJ, Loonen JJ, Bresters D, Versluys B, Neggers SJCMM, Jaspers MWM, Hauptmann M, van der Heiden-van der Loo M, Visser O, Kremer LCM, Ronckers CM; DCOG LATER Study Group. Long-Term Risk of Subsequent Malignant Neoplasms After Treatment of Childhood Cancer in the DCOG LATER Study Cohort: Role of Chemotherapy. J Clin Oncol. 2017 Jul 10;35(20):2288-2298. doi: 10.1200/JCO.2016.71.6902. Epub 2017 May 22. PMID: 28530852.

Sigurdson AJ, Ronckers CM, Mertens AC, Stovall M, Smith SA, Liu Y, Berkow RL, Hammond S, Neglia JP, Meadows AT, Sklar CA, Robison LL, Inskip PD. Primary thyroid cancer after a first tumour in childhood (the Childhood Cancer Survivor Study): a nested case-control study. Lancet. 2005 Jun 11-17;365(9476):2014-23. doi: 10.1016/S0140-6736(05)66695-0. PMID: 15950715.

Ronckers CM, Erdmann CA, Land CE. Radiation and breast cancer: a review of current evidence. Breast Cancer Res. 2005;7(1):21-32. doi: 10.1186/bcr970. Epub 2004 Nov 23. PMID: 15642178; PMCID: PMC1064116.

Leitlinien

Ronckers CM, Kratz CP, Berrington de Gonzalez A. Cancer-predisposing germline variants and subsequent cancer risk. Lancet Oncol. 2023 Oct;24(10):1059-1061. doi: 10.1016/S1470-2045(23)00461-8. PMID: 37797628.

Mulder RL, Hudson MM, Bhatia S, Landier W, Levitt G, Constine LS, Wallace WH, van Leeuwen FE, Ronckers CM, Henderson TO, Moskowitz CS, Friedman DN, Ng AK, Jenkinson HC, Demoor-Goldschmidt C, Skinner R, Kremer LCM, Oeffinger KC. Updated Breast Cancer Surveillance Recommendations for Female Survivors of Childhood, Adolescent, and Young Adult Cancer From the International Guideline Harmonization Group. J Clin Oncol. 2020 Dec 10;38(35):4194-4207. doi: 10.1200/JCO.20.00562. Epub 2020 Sep 29. PMID: 33078972; PMCID: PMC7723685.

Verbruggen LC, Hudson MM, Bowers DC, Ronckers CM, Armstrong GT, Skinner R et al. Variations in screening and management practices for subsequent asymptomatic meningiomas in childhood, adolescent and young adult cancer survivors. Journal of Neuro-Oncology. 2020 Apr 1;147(2):417-425. doi: 10.1007/s11060-020-03436-5.

Kinderkrebs Epidemiologie

Kuhlen M#, Wellbrock M#, Kunstreich M, Trübenbach C, Ronckers CM, Redlich A#, Erdmann F#. Incidence and temporal patterns of differentiated thyroid carcinoma in children and adolescents in Germany: A pooled analysis based on data from the German Malignant Endocrine Tumor Registry and the German Childhood Cancer Registry. (in Press).

• Evidenz-basierte Medizin (EBM)
• Vorlesung im Rahmen vom Master of Science in Epidemiology (MSE): Childhood Cancer Registration
• Vorlesung im Rahmen vom MSE Wahlmodul "Strahlenepidemiologie": Toxicity after Radiotherapy